Compara mètodes

	COSY	Espectroscòpia infraroja per reflectància total atenuada (ATR-FTIR)	HSQC
Camp	Espectroscòpia	Espectroscòpia	Espectroscòpia
Família	Process / pipeline	Process / pipeline	Process / pipeline
Any d'origen	1976	1961	1980
Autor original	Wüthrich Kurt	Joop Fahrenfort	Anil Kumar
Tipus	Two-dimensional pulse sequence	Vibrational spectroscopy technique	Heteronuclear correlation sequence
Font seminal	Aue, W. P., Bartholdi, E., & Ernst, R. R. (1976). Two-dimensional spectroscopy. Application to nuclear magnetic resonance. The Journal of Chemical Physics, 64(5), 2229-2246.	Harrick, N. J. (1960). Study of physics of internal reflection from metals. Journal of Physics and Chemistry of Solids, 13(2), 143-155.	Bodenhausen, G., & Ruben, D. J. (1981). Natural abundance nitrogen-15 NMR by enhanced heteronuclear spectroscopy. Chemical Physics Letters, 69(2), 185-189.
Àlies	COSY NMR, 2D COSY, 1H-1H COSY	ATR-IR, attenuated total reflectance, FTIR spectroscopy	HSQC NMR, 1H-13C HSQC, heteronuclear correlation
Relacionats	4	3	4
Resum	Correlation Spectroscopy (COSY) is a two-dimensional NMR technique that correlates proton chemical shifts through scalar coupling (J-coupling), revealing which protons are magnetically coupled and hence bonded through multiple bonds. Developed by Aue, Bartholdi, and Ernst in 1976, COSY became one of the most important tools in structural elucidation, enabling chemists to map out proton connectivity patterns and deduce molecular topology without isotopic labeling.	Attenuated Total Reflectance (ATR) Fourier Transform Infrared (FTIR) spectroscopy is a variant of conventional FTIR that measures infrared absorption through evanescent-wave interrogation of samples in direct contact with a high-refractive-index crystal. Developed by Harrick and Fahrenfort in the 1960s, ATR-FTIR is now the dominant form of FTIR spectroscopy, enabling rapid, non-destructive characterization of organic compounds, polymers, coatings, and biological materials without extensive sample preparation.	Heteronuclear Single-Quantum Coherence (HSQC) is a 2D NMR technique that correlates proton and carbon-13 (or other heteronuclei) chemical shifts through one-bond coupling constants (1JHX). Developed in the early 1980s, HSQC rapidly became the workhorse of structural chemistry because it directly maps which carbons bear which protons, providing a comprehensive view of carbon skeleton connectivity and substitution patterns.