Compara mètodes

	Escalat Farmacocinètic Al·lomètric	Cinètica de Michaelis-Menten
Camp	Farmacologia	Farmacologia
Família	Process / pipeline	Process / pipeline
Any d'origen	1989	1913
Autor original	John Mordenti	Leonor Michaelis and Maud Menten
Tipus	inter-species extrapolation	mechanistic model
Font seminal	Mordenti, J., & Chappell, W. (1989). The use of allometric scaling in toxicokinetic studies. Fundamental and Applied Toxicology, 13(2), 335-346.	Michaelis, L., & Menten, M. L. (1913). Die Kinetik der Invertinwirkung. Biochemische Zeitschrift, 49, 333-369.
Àlies	allometric scaling, inter-species extrapolation, FIH dose prediction	MM kinetics, Michaelis constant, Vmax
Relacionats	3	2
Resum	Allometric scaling is a mathematical approach for predicting human pharmacokinetics from preclinical animal data using body weight relationships. Developed systematically by Mordenti and colleagues in the late 1980s, it enables rational first-in-human dose prediction without assuming species-specific metabolic differences.	Michaelis-Menten kinetics describes the rate of enzyme-catalyzed reactions as a function of substrate concentration. Developed by Leonor Michaelis and Maud Menten in 1913, this foundational framework models enzyme catalysis through the rapid-equilibrium approximation and enables prediction of drug metabolism rates in pharmacokinetics.