পদ্ধতির তুলনা করুন

	অভিযোজিত ক্লিনিক্যাল ট্রায়াল ডিজাইন	সিকোয়েন্সিয়াল / গ্রুপ সিকোয়েন্সিয়াল ট্রায়াল ডিজাইন
ক্ষেত্র	পরীক্ষামূলক নকশা	পরীক্ষামূলক নকশা
পরিবার	Hypothesis test	Hypothesis test
উদ্ভবের বছর	1994	1979
প্রবর্তক	Bauer & Köhne	O'Brien & Fleming; Pocock; Lan & DeMets
ধরন	Adaptive hypothesis test with interim analyses	Adaptive stopping trial design
মৌলিক উৎস	Bauer, P. & Köhne, K. (1994). Evaluation of Experiments with Adaptive Interim Analyses. Biometrics, 50(4), 1029–1041.	O'Brien, P.C. & Fleming, T.R. (1979). A Multiple Testing Procedure for Clinical Trials. Biometrics, 35(3), 549–556.
অপর নাম	adaptive design, group sequential design, sample size re-estimation, platform trial	group sequential design, adaptive stopping design, Ardışık Deneme Tasarımı (Sequential / Group Sequential)
সম্পর্কিত	3	3
সারসংক্ষেপ	Adaptive clinical trial design is a flexible experimental framework, formalised by Bauer and Köhne in 1994, in which pre-specified rules allow the trial to be modified mid-course — adjusting sample size, treatment arms, or randomisation ratios — based on accumulating interim data while rigorously controlling the Type I error rate.	Sequential and group sequential trial designs allow a study to be stopped early — or continued — based on interim analyses conducted as data accumulate. The core framework was formalised by O'Brien and Fleming in 1979 and extended by Lan and DeMets's alpha-spending approach, and it controls the overall Type I error rate across all planned looks by pre-specifying both efficacy and futility boundaries before enrolment begins.