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| Мрежово епигенетомно-широко асоциативно изследване (Network EWAS)× | Мрежово базиран GWAS× | |
|---|---|---|
| Област | Биоинформатика | Биоинформатика |
| Семейство | Process / pipeline | Process / pipeline |
| Година на възникване≠ | 2010s, consolidating 2012–2018 | 2011–2013 (early tools); mature framework by 2015 |
| Създател≠ | Adapted from EWAS (Rakyan et al., 2011) and network-based genomic methods (e.g., Ideker & Sharan, 2008) | Jia et al. (dmGWAS, 2011); Baranzini et al.; multiple concurrent groups |
| Тип≠ | Integrative epigenomic analysis | Network-augmented association analysis |
| Основополагащ източник≠ | Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011). Epigenome-wide association studies for common human diseases. Nature Reviews Genetics, 12(8), 529–541. link ↗ | Wang, Q., Yu, H., Zhao, Z., & Jia, P. (2015). EW_dmGWAS: edge-weighted dense module search for genome-wide association studies and gene expression profiles. Bioinformatics, 31(15), 2591–2594. link ↗ |
| Други названия | network EWAS, network-integrated EWAS, graph-based EWAS, network-based DNA methylation analysis | network GWAS, gene network GWAS, network-informed GWAS, NbGWAS |
| Свързани | 6 | 6 |
| Резюме≠ | Network-based EWAS extends conventional epigenome-wide association studies by overlaying differentially methylated positions or regions onto biological interaction networks — such as protein-protein interaction, co-expression, or gene regulatory networks — to identify functionally coherent epigenetic modules rather than isolated CpG hits. This integration increases statistical power for detecting weak signals and reveals coordinated epigenetic dysregulation across pathways. | Network-based GWAS integrates conventional genome-wide association study results with biological network data — such as protein-protein interaction (PPI) networks or gene co-expression graphs — to identify disease-relevant gene modules or subnetworks. Instead of reporting only the top individual SNPs, this approach propagates association signals through molecular interaction networks, surfacing gene clusters whose collective signal implicates them in complex-trait biology even when no single variant reaches genome-wide significance alone. |
| ScholarGateНабор от данни ↗ |
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