Сравнение на методи

	Мултиомикс епигеномно-широк асоциативен анализ	eQTL анализ
Област	Биоинформатика	Биоинформатика
Семейство	Process / pipeline	Process / pipeline
Година на възникване	2011 (EWAS foundation); multi-omics integration ~2015–2020	2001 (term coined); widely adopted after 2005
Създател	Rakyan, Down, Balding & Beck (EWAS framework); multi-omics integration extended by multiple groups (~2015–2020)	Ritsert C. Jansen & Jan-Peter Nap
Тип	Integrative association study	Association mapping method
Основополагащ източник	Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011). Epigenome-wide association studies for common human diseases. Nature Reviews Genetics, 12(8), 529–541.	Jansen, R. C., & Nap, J.-P. (2001). Genetical genomics: the added value from segregation. Trends in Genetics, 17(7), 388–391.
Други названия	multi-omics EWAS, integrative EWAS, multi-layer epigenome-wide association, multi-omics epigenomic integration	eQTL mapping, expression QTL analysis, transcriptomic QTL analysis, eQTL study
Свързани	4	6
Резюме	A multi-omics epigenome-wide association study (multi-omics EWAS) systematically scans the entire epigenome — typically DNA methylation at CpG sites — for associations with a phenotype of interest, then integrates findings across additional omics layers such as transcriptomics, genomics, proteomics, or metabolomics. By linking epigenetic variation to molecular changes at multiple biological levels simultaneously, this approach identifies regulatory mechanisms and biomarkers that single-omics EWAS cannot resolve.	eQTL analysis identifies genomic loci (variants, typically SNPs) whose genotype statistically associates with variation in the expression level of one or more genes. By jointly profiling DNA-level variation and RNA-level expression in the same individuals, eQTL studies decode the regulatory grammar of the genome — revealing which variants control how much a gene is transcribed, in which tissues, and under what conditions.