So sánh phương pháp

	Ước lượng Hợp lý Tối đa Có Mục tiêu (TMLE)	Trọng số Xác suất Nghịch đảo của Điều trị (IPW / IPTW)
Lĩnh vực	Suy luận nhân quả	Suy luận nhân quả
Họ	Machine learning	Regression model
Năm ra đời	2006	2000
Người khởi xướng	Mark van der Laan & Daniel Rubin	Robins, Hernán & Brumback
Loại	Semiparametric estimator	Causal inference weighting estimator
Công trình gốc	van der Laan, M. J., & Rubin, D. (2006). Targeted maximum likelihood learning. The International Journal of Biostatistics, 2(1).	Robins, J. M., Hernán, M. A., & Brumback, B. (2000). Marginal Structural Models and Causal Inference in Epidemiology. Epidemiology, 11(5), 550-560.
Tên gọi khác	Targeted Learning, TMLE, Targeted MLE, Hedeflenmiş Maksimum Olabilirlik Tahmini	IPW, IPTW, inverse probability of treatment weighting, marginal structural model weighting
Liên quan	3	5
Tóm tắt	Targeted Maximum Likelihood Estimation (TMLE) is a semiparametric, doubly robust causal inference method introduced by Mark van der Laan and Daniel Rubin in 2006. It combines flexible machine learning models for both the outcome and the treatment assignment mechanism, then applies a targeting step that re-fits the initial outcome model specifically to reduce bias for a pre-specified causal estimand such as the average treatment effect. TMLE is widely used in epidemiology, biostatistics, and health economics when estimating causal effects from observational data.	Inverse Probability Weighting is a causal-inference method that assigns each observation a weight equal to the inverse of its probability of receiving the treatment it actually received. Introduced by Robins, Hernán and Brumback (2000) for marginal structural models, it builds a pseudo-population in which treatment is independent of measured confounders, balancing selection bias.