So sánh phương pháp

	Thiết kế Box-Behnken dựa trên rủi ro	Thiết kế Lập phương Trung tâm
Lĩnh vực	Thiết kế thí nghiệm	Thiết kế thí nghiệm
Họ	Process / pipeline	Process / pipeline
Năm ra đời	2005–2009 (QbD-era integration of risk assessment with BBD)	1951
Người khởi xướng	Box & Behnken (BBD, 1960); risk integration formalized under ICH Q8/Q9 pharmaceutical QbD frameworks (~2005–2009)	George E. P. Box and K. B. Wilson
Loại	Response surface experimental design with risk prioritization	Response surface experimental design
Công trình gốc	Box, G. E. P., & Behnken, D. W. (1960). Some new three level designs for the study of quantitative variables. Technometrics, 2(4), 455–475.	Box, G. E. P., & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society: Series B, 13(1), 1–45.
Tên gọi khác	Risk-based BBD, Risk-prioritized Box-Behnken, QbD Box-Behnken design, Risk-informed RSM	CCD, Box-Wilson design, central composite response surface design, rotatable central composite design
Liên quan	4	3
Tóm tắt	Risk-based Box-Behnken Design combines the classical three-level Box-Behnken response surface design with a formal risk assessment step — typically a risk ranking tool such as FMEA or Ishikawa analysis — to prioritize which process or formulation factors deserve experimental investigation. Widely adopted in pharmaceutical Quality by Design (QbD) and engineering process optimization, the approach ensures that experimental resources are directed toward the factor combinations most likely to affect product quality or process performance, reducing unnecessary runs while preserving predictive power.	Central Composite Design (CCD) is a second-order response surface design that allows researchers to efficiently fit a full quadratic model relating multiple continuous input factors to one or more response variables. Introduced by Box and Wilson in 1951, it combines a factorial (or fractional factorial) core, axial (star) points, and center-point replicates into a single unified design, making it the most widely used design for process optimization in engineering, chemistry, and manufacturing.