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| Kết tinh lại× | Lập kế hoạch lộ trình tổng hợp× | |
|---|---|---|
| Lĩnh vực | Hóa học | Hóa học |
| Họ | Process / pipeline | Process / pipeline |
| Năm ra đời≠ | early 19th century | 1969 |
| Người khởi xướng≠ | Organic chemistry tradition | Elias James Corey |
| Loại≠ | Purification technique | Strategic planning methodology |
| Công trình gốc≠ | Pavia, D. L., Lampman, G. M., Kriz, G. S., & Engel, R. G. (2014). A Small-Scale Approach to Organic Laboratory Techniques (4th ed.). Cengage Learning. ISBN: 978-1285749297 | Corey, E. J., & Cheng, X. M. (1991). The Logic of Chemical Synthesis. John Wiley & Sons. ISBN: 978-0471096092 |
| Tên gọi khác≠ | crystallization purification, recrystallisation | retrosynthesis, retrosynthetic analysis, synthetic route design |
| Liên quan | 3 | 3 |
| Tóm tắt≠ | Recrystallization is a classical purification technique in which a solid compound is dissolved in hot solvent, then allowed to crystallize upon cooling, yielding pure crystals while impurities remain in solution. Practiced for centuries in chemistry laboratories, recrystallization remains one of the most effective and accessible methods for purifying organic solids, especially when the target compound has low solubility at low temperatures. | Synthesis route planning, grounded in retrosynthetic analysis, is a strategic approach to designing efficient chemical syntheses. Formalized by Elias James Corey in the 1960s (earning him the Nobel Prize in 1990), this methodology systematically deconstructs target molecules into simpler precursors and starting materials, enabling chemists to discover logical, economical, and practical synthesis routes. |
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