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Phân tích sống còn thực dụng×Cox proportional hazards×
Lĩnh vựcDịch tễ họcDịch tễ học
HọProcess / pipelineProcess / pipeline
Năm ra đờiConceptual framework: 1967; widespread application: 1990s–2000s1972
Người khởi xướngSchwartz & Lellouch (explanatory vs. pragmatic distinction, 1967); extended in survival analysis literature from the 1970s onwardSir David Roxbee Cox
LoạiObservational / experimental hybrid — time-to-event analysis in real-world or pragmatic-trial settingsSemi-parametric regression model
Công trình gốcFord, I., & Norrie, J. (2016). Pragmatic Trials. New England Journal of Medicine, 375(5), 454–463. DOI ↗Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202. DOI ↗
Tên gọi khácreal-world survival analysis, pragmatic time-to-event analysis, effectiveness survival analysis, PSACox regression, Cox PH model, proportional hazards model, CPH
Liên quan55
Tóm tắtPragmatic survival analysis applies time-to-event statistical methods within pragmatic or real-world settings, estimating how long patients survive, remain event-free, or retain treatment benefit under conditions of routine clinical practice. Unlike explanatory survival analyses conducted under tightly controlled trial conditions, the pragmatic variant embraces the heterogeneity, treatment switching, non-adherence, and competing events that characterise real-world patient populations, prioritising external validity over internal precision.The Cox proportional hazards model is a semi-parametric regression method that estimates the effect of one or more covariates on the hazard — the instantaneous rate of an event such as death, relapse, or failure — while making no assumption about the shape of the baseline hazard function. Introduced by David Cox in 1972, it is the dominant tool for multivariable survival analysis in clinical and epidemiological research.
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ScholarGateSo sánh phương pháp: Pragmatic survival analysis · Cox proportional hazards. Truy cập ngày 2026-06-20 từ https://scholargate.app/vi/compare