So sánh phương pháp

	Thử nghiệm thừa số thực dụng	Thử nghiệm ngẫu nhiên theo cụm
Lĩnh vực	Thiết kế thí nghiệm	Nghiên cứu lâm sàng
Họ	Process / pipeline	Process / pipeline
Năm ra đời	2000s–2010s (formal integration)	1999-2000
Người khởi xướng	Synthesized from pragmatic trial methodology (Schwartz & Lellouch, 1967) and factorial design principles (Fisher, 1935); formalized in clinical research contexts in the 2000s–2010s	Campbell, Grimshaw, Elbourne et al.
Loại	Experimental trial design	Research Design
Công trình gốc	Loudon, K., Treweek, S., Sullivan, F., Donnan, P., Thorpe, K. E., & Zwarenstein, M. (2015). The PRECIS-2 tool: designing trials that are fit for purpose. BMJ, 350, h2147.	Campbell, M. K., Grimshaw, J. M., & Elbourne, D. R. (2000). Intracluster correlation coefficients in cluster randomized trials: empirical insights into how should they be reported. BMC Medical Research Methodology, 4, 30.
Tên gọi khác	pragmatic factorial trial, pragmatic factorial RCT, real-world factorial design, PFE	CRT, cluster RCT, cluster trial, group randomization
Liên quan	3	3
Tóm tắt	A pragmatic factorial experiment combines two powerful methodological frameworks: the factorial experimental design — which tests multiple intervention components simultaneously — and the pragmatic trial orientation, which prioritizes real-world applicability, broad eligibility criteria, and flexible delivery conditions. The result is a design that efficiently evaluates which components of a complex intervention work, and whether they interact, while maintaining ecological validity for health, behavioral, and educational research.	A cluster randomized trial (CRT) randomizes intact groups—schools, clinics, villages, or hospital wards—rather than individuals. Developed by Campbell, Grimshaw, and colleagues in the late 1990s to address real-world settings where intervention delivery or contamination occurs at the group level, CRTs are now standard for evaluating population-level, community-based, and policy interventions.