So sánh phương pháp

	Nghiên cứu sinh thái thực dụng	Thử nghiệm lâm sàng ngẫu nhiên thực dụng
Lĩnh vực	Dịch tễ học	Dịch tễ học
Họ	Process / pipeline	Process / pipeline
Năm ra đời	1967–1982 (pragmatic concept 1967; ecological study formalized ~1982)	1967
Người khởi xướng	Morgenstern (ecological study framework); Schwartz & Lellouch (pragmatic design concept)	Daniel Schwartz & Joseph Lellouch
Loại	Observational ecological study with pragmatic framing	Interventional study design
Công trình gốc	Morgenstern, H. (1982). Uses of ecologic analysis in epidemiologic research. American Journal of Public Health, 72(12), 1336–1344.	Schwartz, D., & Lellouch, J. (1967). Explanatory and pragmatic attitudes in therapeutical trials. Journal of Chronic Diseases, 20(8), 637–648.
Tên gọi khác	real-world ecological study, effectiveness ecological study, population-level pragmatic study, pragmatic ecologic design	pragmatic RCT, effectiveness trial, real-world RCT, practical clinical trial
Liên quan	5	6
Tóm tắt	A pragmatic ecological study is an observational epidemiological design that examines associations between exposures and outcomes at the population or group level — using routinely collected, real-world data — with the explicit goal of informing practical public health decisions under everyday conditions. Rather than controlling every variable in a laboratory-like manner, it embraces the complexity and heterogeneity of natural settings to answer effectiveness questions relevant to policy.	A pragmatic randomized clinical trial (pragmatic RCT) is an interventional study that tests whether a treatment works under routine clinical conditions, as opposed to the tightly controlled setting of an explanatory trial. It prioritizes broad eligibility, flexible delivery, and patient-relevant outcomes to answer the question 'Does this treatment work in everyday practice?' rather than 'Can this treatment work under ideal circumstances?' The distinction between pragmatic and explanatory trials was formally articulated by Schwartz and Lellouch in 1967 and operationalized by the PRECIS tool in 2009.