So sánh phương pháp

	Giám sát dược lý PRR/ROR	Mô hình Dược động học Dân số
Lĩnh vực	Dược lý học	Dược lý học
Họ	Process / pipeline	Process / pipeline
Năm ra đời	2002	1992
Người khởi xướng	Arne Melander and colleagues	Lewis Sheiner and Stephen Roush
Loại	safety signal detection	dose-response modeling
Công trình gốc	Szarfman, A., Tonning, J. M., Doraiswamy, P. M., & Osgood, D. J. (2002). Pharmacovigilance in the post-marketing setting: establishing causal links between drugs and adverse events. Drug Safety, 25(9), 619-631.	Dahlström, B., & Nyberg, L. (1993). Population pharmacokinetics and pharmacodynamics. Clinical Pharmacokinetics, 24(1), 45-57.
Tên gọi khác	PRR, ROR, signal detection, adverse event monitoring	PopPD, population PD, hierarchical PD modeling
Liên quan	3	3
Tóm tắt	Proportional Reporting Ratio (PRR) and Reporting Odds Ratio (ROR) are statistical methods for detecting safety signals in spontaneous adverse event reporting databases. Developed and formalized by researchers in the early 2000s, these measures identify drug-adverse event associations that warrant further investigation.	Population pharmacodynamic (PopPD) modeling integrates pharmacokinetics with individual dose-response relationships across patient populations to characterize drug efficacy and tolerability. Pioneered by Lewis Sheiner and colleagues, PopPD accounts for inter-individual variability in drug effects and enables rational dose optimization and response prediction.