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| Giám sát dược lý PRR/ROR× | Thử nghiệm tính thấm qua tế bào Caco-2× | |
|---|---|---|
| Lĩnh vực | Dược lý học | Dược lý học |
| Họ | Process / pipeline | Process / pipeline |
| Năm ra đời≠ | 2002 | 1989 |
| Người khởi xướng≠ | Arne Melander and colleagues | Ingrid Hidalgo |
| Loại≠ | safety signal detection | absorption screening |
| Công trình gốc≠ | Szarfman, A., Tonning, J. M., Doraiswamy, P. M., & Osgood, D. J. (2002). Pharmacovigilance in the post-marketing setting: establishing causal links between drugs and adverse events. Drug Safety, 25(9), 619-631. link ↗ | Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96(3), 736-749. DOI ↗ |
| Tên gọi khác≠ | PRR, ROR, signal detection, adverse event monitoring | Caco-2 assay, intestinal permeability, ADME screening |
| Liên quan | 3 | 3 |
| Tóm tắt≠ | Proportional Reporting Ratio (PRR) and Reporting Odds Ratio (ROR) are statistical methods for detecting safety signals in spontaneous adverse event reporting databases. Developed and formalized by researchers in the early 2000s, these measures identify drug-adverse event associations that warrant further investigation. | The Caco-2 assay is an in vitro model system using human colon carcinoma cell monolayers to screen drug intestinal permeability. Developed by Hidalgo and colleagues in 1989, Caco-2 cells differentiate into an epithelial barrier resembling intestinal mucosa, enabling rapid assessment of drug absorption potential and identification of transporter-mediated transport. |
| ScholarGateBộ dữ liệu ↗ |
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