So sánh phương pháp

	Thiết kế Trung tâm Tổ hợp Hỗ trợ Tối ưu hóa	Thiết kế Lập phương Trung tâm
Lĩnh vực	Thiết kế thí nghiệm	Thiết kế thí nghiệm
Họ	Process / pipeline	Process / pipeline
Năm ra đời	1951 (CCD); optimization coupling formalized 1970s–1990s	1951
Người khởi xướng	Box & Wilson (CCD, 1951); optimization integration by Myers, Montgomery & colleagues	George E. P. Box and K. B. Wilson
Loại	Experimental design with mathematical optimization	Response surface experimental design
Công trình gốc	Myers, R. H., Montgomery, D. C., & Anderson-Cook, C. M. (2009). Response Surface Methodology: Process and Product Optimization Using Designed Experiments (3rd ed.). Wiley. ISBN: 978-0470174463	Box, G. E. P., & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society: Series B, 13(1), 1–45.
Tên gọi khác	CCD with optimization, optimized CCD, RSM-CCD optimization, central composite design with response optimization	CCD, Box-Wilson design, central composite response surface design, rotatable central composite design
Liên quan	3	3
Tóm tắt	Optimization-assisted central composite design (CCD) combines the rotatable, second-order experimental layout of central composite design with mathematical optimization algorithms — typically desirability functions, response surface optimization, or metaheuristics — to find the factor settings that simultaneously maximize, minimize, or hit target values for one or more response variables. It is the most widely applied response-surface optimization workflow in chemical, pharmaceutical, food science, and manufacturing engineering.	Central Composite Design (CCD) is a second-order response surface design that allows researchers to efficiently fit a full quadratic model relating multiple continuous input factors to one or more response variables. Introduced by Box and Wilson in 1951, it combines a factorial (or fractional factorial) core, axial (star) points, and center-point replicates into a single unified design, making it the most widely used design for process optimization in engineering, chemistry, and manufacturing.