So sánh phương pháp

	Nghiên cứu trường hợp-chứng đa trung tâm	Thiết kế Nghiên cứu Trường hợp-Đối chứng
Lĩnh vực	Dịch tễ học	Dịch tễ học
Họ	Process / pipeline	Process / pipeline
Năm ra đời	Mid-20th century; multicenter framework formalised 1970s–1980s	1950s (formal methodology); precursors in the 1920s
Người khởi xướng	Epidemiology convention; seminal statistical framework by Breslow & Day (IARC, 1980)	Janet Lane-Claypon (early precursors, 1926); formalized by Brian MacMahon and Jerome Cornfield in the 1950s–1960s
Loại	Observational analytical epidemiological design	Observational analytic study design
Công trình gốc	Breslow, N. E., & Day, N. E. (1980). Statistical Methods in Cancer Research. Volume I: The Analysis of Case-Control Studies. IARC Scientific Publications No. 32. International Agency for Research on Cancer, Lyon. ISBN: 978-9283211327	Schlesselman, J.J. (1982). Case-Control Studies: Design, Conduct, Analysis. Oxford University Press. ISBN: 978-0195027860
Tên gọi khác	multisite case-control study, collaborative case-control study, pooled case-control study, multi-institutional case-control study	case-referent study, case-control design, retrospective case-control, case-control analysis
Liên quan	6	6
Tóm tắt	A multicenter case-control study is an observational design that identifies individuals who have developed a disease (cases) and disease-free comparators (controls) across two or more study sites simultaneously. By pooling recruitment across hospitals, clinics, or geographic regions, the design achieves larger sample sizes, captures exposure variability over broader populations, and improves the statistical power needed to detect modest odds ratios for rare or heterogeneous diseases.	A case-control study is a retrospective observational design in which individuals who have developed a disease or outcome of interest (cases) are compared with individuals who have not (controls) to determine whether prior exposure to a putative risk factor differs between the two groups. The primary measure of association is the odds ratio, which approximates the relative risk when the outcome is rare. Case-control studies are especially efficient for investigating rare diseases and generating etiological hypotheses.