So sánh phương pháp

	Nghiên cứu liên kết toàn bộ hệ gene biểu sinh đa omics	Phân tích eQTL
Lĩnh vực	Tin sinh học	Tin sinh học
Họ	Process / pipeline	Process / pipeline
Năm ra đời	2011 (EWAS foundation); multi-omics integration ~2015–2020	2001 (term coined); widely adopted after 2005
Người khởi xướng	Rakyan, Down, Balding & Beck (EWAS framework); multi-omics integration extended by multiple groups (~2015–2020)	Ritsert C. Jansen & Jan-Peter Nap
Loại	Integrative association study	Association mapping method
Công trình gốc	Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011). Epigenome-wide association studies for common human diseases. Nature Reviews Genetics, 12(8), 529–541.	Jansen, R. C., & Nap, J.-P. (2001). Genetical genomics: the added value from segregation. Trends in Genetics, 17(7), 388–391.
Tên gọi khác	multi-omics EWAS, integrative EWAS, multi-layer epigenome-wide association, multi-omics epigenomic integration	eQTL mapping, expression QTL analysis, transcriptomic QTL analysis, eQTL study
Liên quan	4	6
Tóm tắt	A multi-omics epigenome-wide association study (multi-omics EWAS) systematically scans the entire epigenome — typically DNA methylation at CpG sites — for associations with a phenotype of interest, then integrates findings across additional omics layers such as transcriptomics, genomics, proteomics, or metabolomics. By linking epigenetic variation to molecular changes at multiple biological levels simultaneously, this approach identifies regulatory mechanisms and biomarkers that single-omics EWAS cannot resolve.	eQTL analysis identifies genomic loci (variants, typically SNPs) whose genotype statistically associates with variation in the expression level of one or more genes. By jointly profiling DNA-level variation and RNA-level expression in the same individuals, eQTL studies decode the regulatory grammar of the genome — revealing which variants control how much a gene is transcribed, in which tissues, and under what conditions.