So sánh phương pháp

	Thiết kế thí nghiệm hỗn hợp	Thiết kế Lập phương Trung tâm
Lĩnh vực	Thiết kế thí nghiệm	Thiết kế thí nghiệm
Họ	Hypothesis test	Process / pipeline
Năm ra đời	1958	1951
Người khởi xướng	Henry Scheffé	George E. P. Box and K. B. Wilson
Loại	Constrained mixture experiment	Response surface experimental design
Công trình gốc	Scheffé, H. (1958). Experiments with Mixtures. Journal of the Royal Statistical Society, Series B, 20(2), 344–360.	Box, G. E. P., & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society: Series B, 13(1), 1–45.
Tên gọi khác	mixture experiment, simplex-lattice design, simplex-centroid design, Scheffé mixture design	CCD, Box-Wilson design, central composite response surface design, rotatable central composite design
Liên quan	4	3
Tóm tắt	Mixture experiment design is a class of constrained experimental design in which the factors are the proportions of components in a blend, subject to the constraint that all proportions sum to one. The framework was formalised by Henry Scheffé in 1958 and covers simplex-lattice, simplex-centroid, and D-optimal mixture designs widely used in pharmaceutical formulation, food science, and materials research.	Central Composite Design (CCD) is a second-order response surface design that allows researchers to efficiently fit a full quadratic model relating multiple continuous input factors to one or more response variables. Introduced by Box and Wilson in 1951, it combines a factorial (or fractional factorial) core, axial (star) points, and center-point replicates into a single unified design, making it the most widely used design for process optimization in engineering, chemistry, and manufacturing.