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Phân tích Kaplan-Meier theo phương pháp tổng hợp meta×Cox proportional hazards×
Lĩnh vựcDịch tễ họcDịch tễ học
HọProcess / pipelineProcess / pipeline
Năm ra đời2007–2012 (systematic formalization)1972
Người khởi xướngBuilding on Kaplan & Meier (1958); meta-analytic extension formalized by Tierney et al. (2007) and Guyot et al. (2012)Sir David Roxbee Cox
LoạiQuantitative meta-analytic methodSemi-parametric regression model
Công trình gốcGuyot, P., Ades, A. E., Ouwens, M. J., & Welton, N. J. (2012). Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves. BMC Medical Research Methodology, 12, 9. DOI ↗Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202. DOI ↗
Tên gọi khácKM meta-analysis, pooled Kaplan-Meier analysis, survival meta-analysis, IPD-KM meta-analysisCox regression, Cox PH model, proportional hazards model, CPH
Liên quan45
Tóm tắtMeta-analytic Kaplan-Meier analysis synthesizes time-to-event data across multiple studies by pooling Kaplan-Meier survival estimates, either from reconstructed individual patient data or from summary statistics extracted from published curves. It produces a pooled survival function with confidence bands and enables formal heterogeneity testing across studies, offering higher statistical power and more generalizable survival estimates than any single study alone.The Cox proportional hazards model is a semi-parametric regression method that estimates the effect of one or more covariates on the hazard — the instantaneous rate of an event such as death, relapse, or failure — while making no assumption about the shape of the baseline hazard function. Introduced by David Cox in 1972, it is the dominant tool for multivariable survival analysis in clinical and epidemiological research.
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