So sánh phương pháp

	Thử nghiệm lâm sàng ngẫu nhiên có đối chứng theo cặp	Thử nghiệm lâm sàng ngẫu nhiên đa trung tâm
Lĩnh vực	Dịch tễ học	Dịch tễ học
Họ	Process / pipeline	Process / pipeline
Năm ra đời	Mid-20th century concept; methodological formalization circa 2000–2010	1970s–1980s (widespread adoption for large-scale efficacy trials)
Người khởi xướng	Developed formally in biostatistics literature; Greevy, Imai and colleagues advanced modern frameworks in the 2000s	Evolved from single-center RCT methodology; consolidated through landmark trials such as the MRC streptomycin trial (1948) and large cardiovascular mega-trials of the 1970s–1980s
Loại	Experimental clinical study design	Interventional experimental design
Công trình gốc	Imai, K., King, G., & Nall, C. (2009). The essential role of pair matching in cluster-randomized experiments, with application to the Mexican universal health insurance evaluation. Statistical Science, 24(1), 29–53.	Friedman, L. M., Furberg, C. D., DeMets, D. L., Reboussin, D. M., & Granger, C. B. (2015). Fundamentals of Clinical Trials (5th ed.). Springer. ISBN: 978-3319185385
Tên gọi khác	matched RCT, matched-pair randomized trial, matched randomized controlled trial, covariate-matched RCT	multi-site RCT, multicenter RCT, multinational randomized trial, multicenter controlled trial
Liên quan	6	6
Tóm tắt	A matched randomized clinical trial pairs participants (or clusters) on key baseline characteristics before randomization, then allocates one member of each pair to treatment and the other to control. This design combines the causal validity of randomization with the covariate balance of matching, increasing statistical efficiency and reducing confounding from known prognostic variables without sacrificing the internal validity of a controlled experiment.	A multicenter randomized clinical trial (RCT) is an experimental study in which eligible participants are randomly assigned to intervention or control arms simultaneously across two or more clinical sites. By combining the rigor of randomization with enrollment from geographically or institutionally diverse centers, this design produces large samples and externally valid effect estimates that single-center trials rarely achieve. It is the regulatory gold standard for confirmatory efficacy and safety evaluation of new treatments.