So sánh phương pháp

	Tỷ lệ Chuyển hóa Từ hóa	Hình ảnh khuếch tán Kurtosis	NODDI
Lĩnh vực	Chẩn đoán hình ảnh thần kinh	Chẩn đoán hình ảnh thần kinh	Chẩn đoán hình ảnh thần kinh
Họ	Process / pipeline	Process / pipeline	Process / pipeline
Năm ra đời	1989	2005	2012
Người khởi xướng	Stephen Wolff	Jens Jensen	Hui Zhang
Loại	Tissue microstructure characterization	Microstructural white matter analysis	Microstructural white matter mapping
Công trình gốc	Wolff, S. D., & Balaban, R. S. (1989). Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Journal of Magnetic Resonance Imaging, 10(2), 135–148.	Jensen, J. H., Helpern, J. A., Ramani, A., et al. (2005). Diffusional kurtosis imaging: the quantification of non-Gaussian water diffusion by magnetic resonance imaging. Magnetic Resonance in Medicine, 53(6), 1432–1440.	Zhang, H., Schneider, T., Wheeler-Kingshott, C. A., & Alexander, D. C. (2012). NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. NeuroImage, 61(4), 1000–1016.
Tên gọi khác	MTR, magnetization transfer, MT imaging	DKI, non-Gaussian diffusion, diffusion kurtosis	NODDI, neurite density mapping
Liên quan	3	3	3
Tóm tắt	Magnetisation Transfer Ratio (MTR) is an MRI method that measures the exchange of magnetization between free water protons and protons bound to macromolecules (primarily myelin lipids and proteins). Introduced by Wolff and Balaban in 1989, MTR reflects tissue macromolecular content and is particularly sensitive to myelination, providing a non-invasive estimate of myelin density.	Diffusion Kurtosis Imaging (DKI) is an advanced diffusion MRI technique that quantifies non-Gaussian diffusion of water molecules, providing detailed information about tissue microstructure beyond conventional diffusion tensor imaging. Introduced by Jensen and colleagues in 2005, DKI detects deviations from normal Gaussian diffusion, revealing information about cellular compartmentalization and fiber heterogeneity.	Neurite Orientation Dispersion and Density Imaging (NODDI) is a biophysical diffusion MRI model that quantifies microstructural properties of white matter: neurite density (axonal density), orientation dispersion (fiber coherence), and isotropic diffusion (free water or cerebrospinal fluid). Introduced by Zhang and colleagues in 2012, NODDI provides biologically interpretable metrics directly linking diffusion MRI signals to tissue microstructure.