So sánh phương pháp

	Thiết kế thí nghiệm lai	Thiết kế Lập phương Trung tâm
Lĩnh vực	Thiết kế thí nghiệm	Thiết kế thí nghiệm
Họ	Process / pipeline	Process / pipeline
Năm ra đời	1989–2000s	1951
Người khởi xướng	Multiple contributors; notably Sacks, Welch, Mitchell & Wynn (computer experiments); broader hybrid concept developed across 1980s–2000s	George E. P. Box and K. B. Wilson
Loại	Combined experimental design strategy	Response surface experimental design
Công trình gốc	Santner, T. J., Williams, B. J., & Notz, W. I. (2003). The Design and Analysis of Computer Experiments. Springer. ISBN: 978-1441929921	Box, G. E. P., & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society: Series B, 13(1), 1–45.
Tên gọi khác	hybrid DOE, combined experimental design, mixed experimental design, hybrid experimental strategy	CCD, Box-Wilson design, central composite response surface design, rotatable central composite design
Liên quan	4	3
Tóm tắt	Hybrid design of experiments (hybrid DOE) combines two or more experimental design strategies within a single study to exploit the complementary strengths of each. Common combinations include factorial or fractional-factorial arrays paired with computer simulation runs, space-filling Latin hypercube designs merged with response surface augmentations, or Taguchi orthogonal arrays integrated with response surface methodology. The approach is widely used when a single design type cannot efficiently cover all phases of an engineering investigation — from screening through to optimization.	Central Composite Design (CCD) is a second-order response surface design that allows researchers to efficiently fit a full quadratic model relating multiple continuous input factors to one or more response variables. Introduced by Box and Wilson in 1951, it combines a factorial (or fractional factorial) core, axial (star) points, and center-point replicates into a single unified design, making it the most widely used design for process optimization in engineering, chemistry, and manufacturing.