So sánh phương pháp

	Yếu tố tương đồng f1/f2 trong độ hòa tan	Động học Michaelis-Menten
Lĩnh vực	Dược lý học	Dược lý học
Họ	Process / pipeline	Process / pipeline
Năm ra đời	1996	1913
Người khởi xướng	James Moore and Hector Flanner	Leonor Michaelis and Maud Menten
Loại	similarity testing	mechanistic model
Công trình gốc	Moore, J. W., & Flanner, H. H. (1996). Mathematical comparison of dissolution profiles. Pharmaceutical Technology, 20(6), 64-74.	Michaelis, L., & Menten, M. L. (1913). Die Kinetik der Invertinwirkung. Biochemische Zeitschrift, 49, 333-369.
Tên gọi khác	f1, f2, similarity factor	MM kinetics, Michaelis constant, Vmax
Liên quan	3	2
Tóm tắt	The f1 and f2 factors are dimensionless statistical measures developed by Moore and Flanner to quantify the similarity between two dissolution profiles. Adopted by regulatory agencies (FDA, EMA) as the gold standard for comparing dissolution curves, these factors enable rapid assessment of whether formulation changes significantly impact drug release.	Michaelis-Menten kinetics describes the rate of enzyme-catalyzed reactions as a function of substrate concentration. Developed by Leonor Michaelis and Maud Menten in 1913, this foundational framework models enzyme catalysis through the rapid-equilibrium approximation and enables prediction of drug metabolism rates in pharmacokinetics.