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| Mô hình chữa bệnh hỗn hợp× | Ước lượng sống còn Kaplan-Meier× | Kiểm định Log-Rank để so sánh các đường cong sống sót× | |
|---|---|---|---|
| Lĩnh vực | Phân tích sống còn | Phân tích sống còn | Phân tích sống còn |
| Họ | Survival analysis | Survival analysis | Survival analysis |
| Năm ra đời≠ | 1949 | 1958 | 1966 |
| Người khởi xướng≠ | Boag, J. W. | Kaplan, E. L. & Meier, P. | Mantel, N. |
| Loại≠ | Parametric mixture survival model | Non-parametric survival estimator | Non-parametric hypothesis test |
| Công trình gốc≠ | Boag, J. W. (1949). Maximum Likelihood Estimates of the Proportion of Patients Cured. Journal of the Royal Statistical Society B, 11(1), 15–53. link ↗ | Kaplan, E. L. & Meier, P. (1958). Nonparametric Estimation from Incomplete Observations. Journal of the American Statistical Association, 53(282), 457–481. DOI ↗ | Mantel, N. (1966). Evaluation of Survival Data and Two New Rank Order Statistics Arising in Its Consideration. Cancer Chemotherapy Reports, 50(3), 163–170. link ↗ |
| Tên gọi khác≠ | cure fraction model, cure rate model, bounded cumulative hazard model, İyileşme Modeli (Mixture Cure Model) | product-limit estimator, km curve, kaplan-meier sağkalım analizi | Mantel log-rank test, Mantel-Cox test, log-rank sağkalım testi, Log-Rank Testi |
| Liên quan | 2 | 2 | 2 |
| Tóm tắt≠ | The mixture cure model, first proposed by Boag in 1949 for cancer survival data, is a parametric survival model that explicitly accounts for a fraction of subjects who will never experience the event of interest — the so-called cured or immune fraction. It is the appropriate tool whenever the Kaplan-Meier curve levels off into a long, stable plateau rather than continuing to decline, indicating that a proportion of subjects are permanently event-free. | The Kaplan-Meier estimator, introduced by Kaplan and Meier in 1958, is a non-parametric method that estimates the survival curve — the probability of remaining event-free over time — from right-censored time-to-event data. The log-rank test is the companion procedure used to compare survival curves between groups. | The log-rank test, developed by Nathan Mantel in 1966, is a non-parametric hypothesis test that compares the overall survival experience of two or more groups throughout the entire follow-up period. It is the standard companion to Kaplan-Meier curves and determines whether observed differences between curves are statistically meaningful. |
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