So sánh phương pháp

	Thiết kế thử nghiệm chéo thích ứng	Thử nghiệm đối chứng ngẫu nhiên thích ứng
Lĩnh vực	Thiết kế thí nghiệm	Thiết kế thí nghiệm
Họ	Process / pipeline	Process / pipeline
Năm ra đời	Late 1990s–2000s	1980s–2000s (formalized; earlier sequential testing roots from Wald, 1947)
Người khởi xướng	Developed through convergence of crossover trial methodology (Senn, Williams) and adaptive design methods (Bauer, Köhne, Chow, Chang)	Donald Berry and others; foundational adaptive trial methods developed through 1980s–2000s biostatistics literature
Loại	Experimental design — hybrid adaptive/crossover	Experimental design — adaptive variant of RCT
Công trình gốc	Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman & Hall/CRC. ISBN: 978-1584888468	Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman & Hall/CRC. ISBN: 978-1584887690
Tên gọi khác	adaptive crossover trial, adaptive crossover design, crossover adaptive trial, ACE design	Adaptive RCT, Response-adaptive RCT, Adaptive clinical trial, Platform trial
Liên quan	5	6
Tóm tắt	An adaptive crossover experiment combines the within-subject efficiency of crossover designs — where each participant receives multiple treatments in sequence — with pre-specified adaptive rules that allow trial parameters to be modified based on interim data. Each participant acts as their own control across treatment periods, while ongoing accumulating evidence can trigger pre-planned changes such as sample size re-estimation, treatment arm dropping, or allocation ratio adjustment, all governed by a formal adaptation plan to preserve inferential validity.	An adaptive randomized controlled trial (adaptive RCT) is an experimental design in which pre-specified rules allow modifications to the trial while it is ongoing — such as changing allocation ratios, dropping underperforming arms, or stopping early for efficacy or futility — based on accumulating interim data. These adaptations are planned before the trial starts and governed by statistical rules to preserve Type I error control and validity.