So sánh phương pháp

	COSY	Quang phổ khối cộng hưởng cyclotron ion biến đổi Fourier (FT-ICR)
Lĩnh vực	Quang phổ học	Quang phổ học
Họ	Process / pipeline	Process / pipeline
Năm ra đời	1976	1974
Người khởi xướng	Wüthrich Kurt	Alan Marshall
Loại	Two-dimensional pulse sequence	Mass spectrometry technique
Công trình gốc	Aue, W. P., Bartholdi, E., & Ernst, R. R. (1976). Two-dimensional spectroscopy. Application to nuclear magnetic resonance. The Journal of Chemical Physics, 64(5), 2229-2246.	Comisarow, M. B., & Marshall, A. G. (1974). Fourier transform ion cyclotron resonance spectroscopy. Chemical Physics Letters, 25(2), 282-283.
Tên gọi khác	COSY NMR, 2D COSY, 1H-1H COSY	FT-ICR-MS, Fourier Transform ICR, ICR mass spectrometry
Liên quan	4	4
Tóm tắt	Correlation Spectroscopy (COSY) is a two-dimensional NMR technique that correlates proton chemical shifts through scalar coupling (J-coupling), revealing which protons are magnetically coupled and hence bonded through multiple bonds. Developed by Aue, Bartholdi, and Ernst in 1976, COSY became one of the most important tools in structural elucidation, enabling chemists to map out proton connectivity patterns and deduce molecular topology without isotopic labeling.	Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometry is an advanced analytical technique that combines magnetic confinement of ions with Fourier transform data processing to achieve exceptional mass accuracy and resolution. Developed by Comisarow and Marshall in 1974, FT-ICR-MS enables the determination of exact masses and elemental compositions of complex molecules, making it invaluable for environmental chemistry, metabolomics, petroleum characterization, and structural elucidation of unknowns.