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| Sắc ký cột× | Lập kế hoạch lộ trình tổng hợp× | |
|---|---|---|
| Lĩnh vực | Hóa học | Hóa học |
| Họ | Process / pipeline | Process / pipeline |
| Năm ra đời≠ | 1903 | 1969 |
| Người khởi xướng≠ | Mikhail Tsvet | Elias James Corey |
| Loại≠ | Chromatographic separation technique | Strategic planning methodology |
| Công trình gốc≠ | Skoog, D. A., Holler, F. J., & Crouch, S. R. (2017). Principles of Instrumental Analysis (7th ed.). Cengage Learning. ISBN: 978-1305577213 | Corey, E. J., & Cheng, X. M. (1991). The Logic of Chemical Synthesis. John Wiley & Sons. ISBN: 978-0471096092 |
| Tên gọi khác≠ | liquid chromatography, column liquid chromatography | retrosynthesis, retrosynthetic analysis, synthetic route design |
| Liên quan | 3 | 3 |
| Tóm tắt≠ | Column chromatography is a liquid separation technique in which a stationary phase (typically silica gel or alumina) is packed into a vertical column, and a mobile phase (solvent) percolates through it to separate mixture components. Pioneered by Mikhail Tsvet in 1903, column chromatography remains the workhorse of organic chemistry laboratories for purifying reaction products and isolating target compounds. | Synthesis route planning, grounded in retrosynthetic analysis, is a strategic approach to designing efficient chemical syntheses. Formalized by Elias James Corey in the 1960s (earning him the Nobel Prize in 1990), this methodology systematically deconstructs target molecules into simpler precursors and starting materials, enabling chemists to discover logical, economical, and practical synthesis routes. |
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