So sánh phương pháp

	Thí nghiệm Yếu tố Ngẫu nhiên theo Cụm	Phép thử kiểm soát ngẫu nhiên theo thừa số
Lĩnh vực	Thiết kế thí nghiệm	Thiết kế thí nghiệm
Họ	Process / pipeline	Process / pipeline
Năm ra đời	1990s (formalized in group-randomized trial literature)	1926 (Fisher factorial foundations); 2000s–2010s (clinical factorial RCT formalization)
Người khởi xướng	David M. Murray and colleagues; Allan Donner & Neil Klar	R. A. Fisher (factorial design foundations); adapted into clinical trials via MOST framework (Collins et al., 2014)
Loại	Experimental design	Experimental trial design
Công trình gốc	Murray, D. M. (1998). Design and Analysis of Group-Randomized Trials. Oxford University Press. ISBN: 978-0195120912	Collins, L. M., Dziak, J. J., Kugler, K. C., & Trail, J. B. (2014). Factorial experiments: Efficient tools for evaluation of intervention components. American Journal of Preventive Medicine, 47(4), 498–504.
Tên gọi khác	cluster-randomized factorial design, group-randomized factorial trial, CRT factorial, clustered factorial experiment	Factorial RCT, factorial trial, multi-factor RCT, factorial experiment with randomization
Liên quan	5	6
Tóm tắt	A cluster randomized factorial experiment assigns intact groups (clusters such as schools, clinics, or communities) at random to all combinations of two or more treatment factors, enabling simultaneous evaluation of multiple interventions and their interactions while respecting the natural grouping of participants. It merges the logistical and ethical advantages of cluster randomization with the efficiency of factorial design.	A factorial randomized controlled trial (factorial RCT) is an experimental design in which participants are randomly assigned to every possible combination of two or more independent factors (treatments or intervention components) simultaneously. This allows researchers to estimate the main effect of each factor and their interactions within a single, efficient trial, rather than running separate experiments for each factor.