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| Thử nghiệm thích ứng ngẫu nhiên theo cụm× | Thử nghiệm kiểm soát ngẫu nhiên theo khối (Blocked Randomized Controlled Trial)× | |
|---|---|---|
| Lĩnh vực | Thiết kế thí nghiệm | Thiết kế thí nghiệm |
| Họ | Process / pipeline | Process / pipeline |
| Năm ra đời≠ | 2000s–2010s | 1920s (Fisher's blocking principle); applied to RCTs from the 1940s onward |
| Người khởi xướng≠ | Synthesised from cluster randomization methodology (Donner, 1978; Donner & Klar, 2000) and adaptive design frameworks (Bauer & Kohne, 1994; Pallmann et al., 2018) | R. A. Fisher (blocking principle); systematic RCT application by Bradford Hill and later Pocock, Friedman et al. |
| Loại | Experimental design | Experimental design |
| Công trình gốc≠ | Hayes, R. J., & Moulton, L. H. (2017). Cluster Randomised Trials (2nd ed.). CRC Press / Chapman & Hall. ISBN: 978-1498728225 | Friedman, L. M., Furberg, C. D., DeMets, D. L., Reboussin, D. M., & Granger, C. B. (2010). Fundamentals of Clinical Trials (4th ed.). Springer. ISBN: 978-1441915856 |
| Tên gọi khác | adaptive cluster RCT, adaptive group-randomized trial, cluster adaptive design, adaptive cluster trial | blocked RCT, block-randomized trial, stratified block randomization trial, permuted block randomization |
| Liên quan | 5 | 5 |
| Tóm tắt≠ | A cluster randomized adaptive experiment combines two methodological principles: (1) intact groups such as schools, clinics, or villages are randomly assigned to treatment conditions rather than individuals, and (2) pre-specified rules allow the design to be modified during the trial based on accumulating cluster-level data. Adaptations may include dropping underperforming arms, reallocating clusters, or adjusting sample size, while maintaining statistical validity and controlling Type I error. | A blocked randomized controlled trial (blocked RCT) uses permuted-block randomization to ensure that treatment groups remain balanced in size — and optionally in key characteristics — throughout recruitment. Within each block of fixed or randomly varied size, all treatment allocations are present in equal numbers, so imbalance cannot accumulate even if the trial is stopped early. This makes blocked RCTs the standard randomization approach in clinical and behavioral intervention research. |
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