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| Thí nghiệm giai thừa đầy đủ theo khối× | Thử nghiệm kiểm soát ngẫu nhiên theo khối (Blocked Randomized Controlled Trial)× | |
|---|---|---|
| Lĩnh vực | Thiết kế thí nghiệm | Thiết kế thí nghiệm |
| Họ | Process / pipeline | Process / pipeline |
| Năm ra đời≠ | 1935 (Fisher); systematized through 20th-century DOE literature | 1920s (Fisher's blocking principle); applied to RCTs from the 1940s onward |
| Người khởi xướng≠ | R. A. Fisher (blocking principle); full factorial DOE tradition | R. A. Fisher (blocking principle); systematic RCT application by Bradford Hill and later Pocock, Friedman et al. |
| Loại | Experimental design | Experimental design |
| Công trình gốc≠ | Montgomery, D. C. (2017). Design and Analysis of Experiments (9th ed.). Wiley. ISBN: 978-1119113478 | Friedman, L. M., Furberg, C. D., DeMets, D. L., Reboussin, D. M., & Granger, C. B. (2010). Fundamentals of Clinical Trials (4th ed.). Springer. ISBN: 978-1441915856 |
| Tên gọi khác | blocked full factorial design, full factorial with blocking, complete factorial blocked design, BFF design | blocked RCT, block-randomized trial, stratified block randomization trial, permuted block randomization |
| Liên quan≠ | 4 | 5 |
| Tóm tắt≠ | A blocked full factorial experiment tests every combination of all factor levels while grouping experimental runs into homogeneous blocks to isolate a known nuisance variable. This design preserves the power to detect all main effects and interactions of the factors of interest while preventing batch-to-batch, day-to-day, or machine-to-machine variability from inflating experimental error. | A blocked randomized controlled trial (blocked RCT) uses permuted-block randomization to ensure that treatment groups remain balanced in size — and optionally in key characteristics — throughout recruitment. Within each block of fixed or randomly varied size, all treatment allocations are present in equal numbers, so imbalance cannot accumulate even if the trial is stopped early. This makes blocked RCTs the standard randomization approach in clinical and behavioral intervention research. |
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