So sánh phương pháp

	Thử nghiệm lâm sàng giai đoạn III kiểu Bayes	Phân tích tuần tự (Thiết kế tuần tự nhóm)
Lĩnh vực	Dịch tễ học	Thống kê
Họ	Process / pipeline	Hypothesis test
Năm ra đời	1990s–2000s (widespread application)	1977
Người khởi xướng	Donald A. Berry; David J. Spiegelhalter (formalization in clinical context)	P. C. O'Brien & T. R. Fleming; P. C. Pocock
Loại	Confirmatory randomized controlled trial with Bayesian inference	Sequential / adaptive hypothesis test
Công trình gốc	Spiegelhalter, D. J., Abrams, K. R., & Myles, J. P. (2004). Bayesian Approaches to Clinical Trials and Health-Care Evaluation. Wiley. ISBN: 978-0471499756	O'Brien, P.C. & Fleming, T.R. (1979). A Multiple Testing Procedure for Clinical Trials. Biometrics, 35(3), 549–556.
Tên gọi khác	Bayesian confirmatory trial, Bayesian RCT Phase III, Bayesian pivotal trial, BayesCT	sequential testing, group sequential design, interim analysis, Sıralı Analiz (Sequential Testing / Group Sequential Design)
Liên quan	5	5
Tóm tắt	A Bayesian Phase III clinical trial is a large-scale, confirmatory randomized controlled trial that uses Bayesian statistical inference rather than conventional frequentist hypothesis testing to evaluate whether an experimental treatment meets pre-defined efficacy and safety thresholds. By combining prior evidence with accumulating trial data, it quantifies the probability that the treatment effect exceeds a clinically meaningful threshold, enabling more transparent decision-making under uncertainty.	Sequential analysis is a framework for conducting hypothesis tests with pre-planned interim looks at accumulating data, allowing a study to stop early for efficacy or futility while controlling the overall Type I error rate. The group sequential approach was formalised by Pocock (1977) and O'Brien and Fleming (1979), and remains the standard for confirmatory clinical trials and rigorous A/B experiments.