So sánh phương pháp

	Nghiên cứu liên kết toàn bộ bộ gen epigenetic theo Bayes (Bayesian EWAS)	Nghiên cứu liên kết bộ gen trên toàn bộ bộ gen theo phương pháp Bayes
Lĩnh vực	Tin sinh học	Tin sinh học
Họ	Process / pipeline	Process / pipeline
Năm ra đời	2010s (framework developed ~2013–2016)	2007–2009 (formal statistical framework)
Người khởi xướng	Multiple groups; Bayesian EWAS framework advanced by S. Richardson, P.-C. Tsai, J. T. Bell and colleagues	Matthew Stephens, David J. Balding, Jon Wakefield (key formalizers ca. 2007–2009)
Loại	Statistical association analysis	Statistical genetic association analysis
Công trình gốc	Richardson, S., Tsai, P. C., Bell, J. T., & Timpson, N. J. (2016). Bayesian approaches to studying associations between epigenetic marks and phenotypes. International Journal of Epidemiology, 45(3), 694–705.	Stephens, M., & Balding, D. J. (2009). Bayesian statistical methods for genetic association studies. Nature Reviews Genetics, 10(10), 681–690.
Tên gọi khác	Bayesian EWAS, B-EWAS, Bayesian methylation-wide association study, Bayesian epigenetic association analysis	Bayesian GWAS, Bayesian genome-wide association analysis, Bayesian GWA study, BF-GWAS
Liên quan	4	5
Tóm tắt	A Bayesian EWAS is a genome-scale association analysis that links epigenetic marks — most commonly CpG-site DNA methylation — to a phenotype or trait of interest, replacing or supplementing the classical frequentist p-value framework with a Bayesian probabilistic model. It yields posterior probabilities of association and credible intervals for each CpG site, allowing formal incorporation of prior biological knowledge and more principled handling of the multiple-testing burden intrinsic to testing hundreds of thousands of sites simultaneously.	Bayesian GWAS applies Bayesian statistical inference to genome-wide association studies, replacing classical p-value thresholds with Bayes factors and posterior probabilities. This framework naturally incorporates prior knowledge about effect sizes and variant frequencies, quantifies evidence for association on a continuous scale, and supports principled fine-mapping of causal variants within associated loci. It is widely used in complex trait genetics, population genomics, and translational research where uncertainty quantification and multi-variant modeling matter.