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| Thiết kế thử nghiệm nhóm đối chứng thích ứng× | Nghiên cứu đối chứng ngẫu nhiên (RCT)× | |
|---|---|---|
| Lĩnh vực | Thiết kế thí nghiệm | Thiết kế thí nghiệm |
| Họ≠ | Process / pipeline | Hypothesis test |
| Năm ra đời≠ | 1994 (formal adaptive framework); wider adoption 2000s–2010s | 1948 |
| Người khởi xướng≠ | Peter Bauer and Klaus Kohne (adaptive interim analysis framework, 1994); broader adaptive design methodology developed by Scott Chow and Mark Chang | James Lind (early precursor, 1747); modern formulation: Austin Bradford Hill & Medical Research Council (1948) |
| Loại≠ | Adaptive experimental design | Interventional comparative study |
| Công trình gốc≠ | Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman and Hall/CRC. ISBN: 978-1584886760 | Schulz, K.F., Altman, D.G., Moher, D., for the CONSORT Group (2010). CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials. BMJ, 340, c332. DOI ↗ |
| Tên gọi khác | adaptive controlled experiment, adaptive two-arm controlled design, adaptive parallel-group design, flexible controlled trial design | RCT, randomised controlled trial, clinical trial, Randomize Kontrollü Çalışma (RCT) Tasarımı |
| Liên quan≠ | 4 | 7 |
| Tóm tắt≠ | An adaptive control group experimental design is an experiment that assigns participants to at least one treatment arm and one concurrent control group, while allowing pre-specified modifications to the trial — such as sample size re-estimation, early stopping, or allocation ratio changes — based on accumulating data. Adaptations are governed by decision rules established before the study begins, preserving Type I error control while improving efficiency. | A randomized controlled trial (RCT) is the gold standard experimental design in clinical and health research, in which participants are randomly allocated to a treatment group or a control group so that the effect of an intervention can be measured with the highest possible degree of internal validity. The modern parallel-group RCT was formalized by Austin Bradford Hill and the Medical Research Council in their landmark streptomycin trial of 1948, and its reporting is governed today by the CONSORT 2010 guidelines (Schulz et al., 2010). |
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