So sánh phương pháp

	Thiết kế thử nghiệm nhóm đối chứng thích ứng	Thử nghiệm đối chứng ngẫu nhiên thích ứng
Lĩnh vực	Thiết kế thí nghiệm	Thiết kế thí nghiệm
Họ	Process / pipeline	Process / pipeline
Năm ra đời	1994 (formal adaptive framework); wider adoption 2000s–2010s	1980s–2000s (formalized; earlier sequential testing roots from Wald, 1947)
Người khởi xướng	Peter Bauer and Klaus Kohne (adaptive interim analysis framework, 1994); broader adaptive design methodology developed by Scott Chow and Mark Chang	Donald Berry and others; foundational adaptive trial methods developed through 1980s–2000s biostatistics literature
Loại	Adaptive experimental design	Experimental design — adaptive variant of RCT
Công trình gốc	Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman and Hall/CRC. ISBN: 978-1584886760	Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman & Hall/CRC. ISBN: 978-1584887690
Tên gọi khác	adaptive controlled experiment, adaptive two-arm controlled design, adaptive parallel-group design, flexible controlled trial design	Adaptive RCT, Response-adaptive RCT, Adaptive clinical trial, Platform trial
Liên quan	4	6
Tóm tắt	An adaptive control group experimental design is an experiment that assigns participants to at least one treatment arm and one concurrent control group, while allowing pre-specified modifications to the trial — such as sample size re-estimation, early stopping, or allocation ratio changes — based on accumulating data. Adaptations are governed by decision rules established before the study begins, preserving Type I error control while improving efficiency.	An adaptive randomized controlled trial (adaptive RCT) is an experimental design in which pre-specified rules allow modifications to the trial while it is ongoing — such as changing allocation ratios, dropping underperforming arms, or stopping early for efficacy or futility — based on accumulating interim data. These adaptations are planned before the trial starts and governed by statistical rules to preserve Type I error control and validity.