Порівняння методів
Переглядайте обрані методи поруч; рядки з відмінностями підсвічено.
| Епігеномне повногеномне асоціативне дослідження часових рядів× | Епігеномне повногеномне дослідження асоціацій (EWAS)× | |
|---|---|---|
| Галузь | Біоінформатика | Біоінформатика |
| Родина | Process / pipeline | Process / pipeline |
| Рік появи≠ | 2010s | 2008–2011 (term and framework established c. 2011) |
| Автор методу≠ | Extended from EWAS (Rakyan et al., 2011); longitudinal designs formalised by multiple groups ~2010s | Rakyan, Down, Balding & Beck (conceptual framework); Illumina arrays enabled large-scale application |
| Тип≠ | Longitudinal epigenomic association pipeline | Population-scale epigenomic association study |
| Основоположне джерело≠ | Pidsley, R., Zotenko, E., Peters, T. J., Lawrence, M. G., Risbridger, G. P., Molloy, P., ... & Clark, S. J. (2016). Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling. Genome Biology, 17(1), 208. link ↗ | Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011). Epigenome-wide association studies for common human diseases. Nature Reviews Genetics, 12(8), 529–541. DOI ↗ |
| Інші назви | time-series EWAS, longitudinal EWAS, repeated-measures EWAS, dynamic methylation association study | EWAS, methylome-wide association study, epigenetic association study, DNA methylation association study |
| Пов'язані≠ | 3 | 5 |
| Підсумок≠ | A time-series epigenome-wide association study (time-series EWAS) extends the classic cross-sectional EWAS design to longitudinal settings, measuring DNA methylation across the entire epigenome at multiple time points within the same subjects. The goal is to identify CpG sites whose methylation levels change systematically over time, or to characterise how epigenetic associations with an exposure or phenotype evolve across developmental stages, treatment periods, or disease trajectories. | An epigenome-wide association study (EWAS) is a hypothesis-free, genome-scale method that systematically tests whether epigenetic marks — predominantly CpG-site DNA methylation — differ between individuals with and without a trait, disease, or exposure. By scanning hundreds of thousands of genomic positions simultaneously, EWAS identifies loci where the epigenome is reproducibly associated with a phenotype, offering a layer of biological regulation that classical GWAS does not capture. |
| ScholarGateНабір даних ↗ |
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