Process / pipelineBioinformatics / omics
Machine Learning-Assisted Microbiome Diversity Analysis
Machine learning-assisted microbiome diversity analysis integrates classical alpha and beta diversity metrics with supervised or unsupervised ML models to classify host phenotypes, identify discriminant taxa, and uncover community-level signatures from 16S rRNA or shotgun metagenomic data. It extends traditional diversity analysis beyond descriptive statistics toward predictive and explanatory modelling across health, ecology, and environmental science.
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Sources
- Pasolli, E., Truong, D. T., Malik, F., Waldron, L., & Segata, N. (2016). Machine Learning Meta-analysis of Large Metagenomic Datasets: Tools and Biological Insights. PLOS Computational Biology, 12(7), e1004977. link ↗
- Wirbel, J., Pyl, P. T., Kartal, E., Zych, K., Kashani, A., Milanese, A., ... & Zeller, G. (2019). Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer. Nature Medicine, 25(4), 679–689. link ↗