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Single-cell Copy Number Variation Analysis/Ushahidi
Rekodi ya ushahidi wa mbinu

Single-cell Copy Number Variation Analysis

Single-cell copy number variation (scCNV) analysis detects gains and losses of genomic segments within individual cells, enabling researchers to resolve intratumor heterogeneity, reconstruct clonal evolution, and distinguish malignant from normal cells at single-cell resolution. It can be applied to single-cell whole-genome sequencing data directly or inferred from read-depth signals in scRNA-seq or scATAC-seq experiments.

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Rekodi ya chanzo

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Single-cell Copy Number Variation Analysis
Rekodi ya mbinu ya kiajenda · process-pipeline / bioinformatics
  • Garvin, T., Aboukhalil, R., Kendall, J., Baslan, T., Atwal, G. S., Hicks, J., Wigler, M., & Schatz, M. C. (2015). Interactive analysis and assessment of single-cell copy-number variations. Nature Methods, 12(11), 1058–1060. · URL
  • Gao, R., Bai, S., Henderson, Y. C., Lin, Y., Schalck, A., Yan, Y., Kumar, T., Hu, M., Sei, E., Davis, A., Wang, F., Shaitelman, S. F., Wang, J. R., Chen, K., Moulder, S., Lai, S. Y., & Navin, N. E. (2021). Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes. Nature Biotechnology, 39(5), 599–608. · URL
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Taxonomic bucketCopy Number Variation Analysismachine-suggested · Relational suggestion, not evidence.Taxonomic bucketSingle-cell epigenome-wide association studymachine-suggested · Relational suggestion, not evidence.Taxonomic bucketSingle-cell GWASmachine-suggested · Relational suggestion, not evidence.Taxonomic bucketSingle-cell RNA-seq analysismachine-suggested · Relational suggestion, not evidence.Taxonomic bucketSingle-cell RNA-seq differential expressionmachine-suggested · Relational suggestion, not evidence.Taxonomic bucketVariant Callingmachine-suggested · Relational suggestion, not evidence.

Hali ya ushahidi

Sources recorded, not reviewed

Bibliographic sources are present. Claim-level evidence review has not been performed.

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