Jämför metoder

	Svullnad och nedbrytning	Dynamisk mekanisk analys
Ämnesområde	Biomaterial	Biomaterial
Familj	Process / pipeline	Process / pipeline
Ursprungsår	1960	1960
Upphovsperson	Wichterle and Lim	Ferry and Schwarzl
Typ	Kinetic assay	Rheological characterization
Ursprungskälla	Wichterle, O., & Lim, D. (1960). Hydrophilic gels for biological use. Nature, 185(4706), 117-118.	Menard, K. P. (2008). Dynamic mechanical analysis: a practical introduction (2nd ed.). CRC Press.
Alias	hydrogel swelling, polymer degradation, mass loss assay	DMA, rheological analysis, viscoelastic testing
Närliggande	4	3
Sammanfattning	The swelling and degradation assay measures how biomaterial scaffolds absorb water (swelling) and lose mass over time due to degradation. Developed by Wichterle and Lim in 1960 for hydrogels, the assay is fundamental for characterizing hydrogels, synthetic polymers, and composite scaffolds intended for tissue engineering. The assay provides quantitative data on swelling kinetics (equilibrium water content, swelling ratio), degradation kinetics (mass loss rate, half-life), and mechanisms of degradation (chain scission, enzymatic breakdown).	Dynamic mechanical analysis (DMA) measures the viscoelastic properties of materials—their elastic stiffness and viscous damping—by applying a sinusoidal stress or strain and measuring the phase lag and amplitude of the material's response. Developed from rheology principles in the 1960s and formalized by Ferry, Schwarzl, and others, DMA provides quantitative measures of how polymeric biomaterials respond to time-dependent and frequency-dependent mechanical stimuli. Key outputs include the storage modulus (elastic component), loss modulus (viscous component), and loss tangent (tan δ), which together characterize the material's mechanical behavior across temperature and frequency ranges.