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	Standard additionsmetoden	Jonkromatografi
Ämnesområde	Analytisk kemi	Analytisk kemi
Familj	Process / pipeline	Process / pipeline
Ursprungsår	1920s	1975
Upphovsperson	Analytical chemistry practice	Hamish Small
Typ	matrix-compensating calibration technique	separation and analysis technique
Ursprungskälla	Harris, D. C. (2010). Quantitative Chemical Analysis (8th ed.). Freeman. ISBN: 978-1429218153	Small, H., Stevens, T. S., & Bauman, W. C. (1989). Novel ion exchange chromatographic method using conductometric detection. Analytical Chemistry, 47(11), 1801–1809.
Alias	spiking method, known-addition method, matrix matching	IC, ion-exchange chromatography, IEC
Närliggande	5	5
Sammanfattning	The standard addition method is a quantitative analytical technique that determines the concentration of an unknown analyte by measuring the response before and after adding a known quantity of the analyte (a standard) to the sample itself. This approach compensates for matrix effects and interference from other sample components, making it invaluable when analyzing complex matrices (biological fluids, environmental samples, geological materials) where the sample composition profoundly affects the measured signal. The standard addition method is widely recognized in analytical chemistry as a primary quantification strategy when external calibration is compromised by matrix variability.	Ion chromatography is a liquid chromatography method that separates ions and polar molecules based on their relative affinity for the ion exchange resin in the column. Developed by Hamish Small in 1975, it combines ion-exchange separation with conductivity detection, enabling rapid, sensitive, and simultaneous determination of multiple ions in a single analysis. Ion chromatography has become an indispensable tool for monitoring environmental pollutants, analyzing food and pharmaceutical products, and studying complex ionic mixtures.