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| Pragmatic Full Factorial Experiment× | Faktoriell randomiserad kontrollerad studie× | |
|---|---|---|
| Ämnesområde | Försöksplanering | Försöksplanering |
| Familj | Process / pipeline | Process / pipeline |
| Ursprungsår≠ | 1920s (factorial); 1967/2009 (pragmatic framework) | 1926 (Fisher factorial foundations); 2000s–2010s (clinical factorial RCT formalization) |
| Upphovsperson≠ | Full factorial: R.A. Fisher (1920s); Pragmatic framing: Schwartz & Lellouch (1967), formalized by Thorpe et al. (2009) | R. A. Fisher (factorial design foundations); adapted into clinical trials via MOST framework (Collins et al., 2014) |
| Typ≠ | Experimental design | Experimental trial design |
| Ursprungskälla≠ | Thorpe, K. E., Zwarenstein, M., Oxman, A. D., Treweek, S., Furberg, C. D., Altman, D. G., ... & Chalmers, I. (2009). A pragmatic-explanatory continuum indicator summary (PRECIS): a tool to help trial designers. Journal of Clinical Epidemiology, 62(5), 464-475. DOI ↗ | Collins, L. M., Dziak, J. J., Kugler, K. C., & Trail, J. B. (2014). Factorial experiments: Efficient tools for evaluation of intervention components. American Journal of Preventive Medicine, 47(4), 498–504. DOI ↗ |
| Alias | pragmatic factorial trial, real-world full factorial design, effectiveness full factorial experiment, pragmatic 2^k experiment | Factorial RCT, factorial trial, multi-factor RCT, factorial experiment with randomization |
| Närliggande | 6 | 6 |
| Sammanfattning≠ | A pragmatic full factorial experiment combines the complete crossing of all factor levels (the full factorial structure) with the broad eligibility criteria, flexible delivery, and real-world conditions of a pragmatic trial. Every possible combination of factors is tested simultaneously, yielding both main effects and all interaction effects, while deliberately relaxing strict laboratory controls to reflect how interventions actually operate in practice. | A factorial randomized controlled trial (factorial RCT) is an experimental design in which participants are randomly assigned to every possible combination of two or more independent factors (treatments or intervention components) simultaneously. This allows researchers to estimate the main effect of each factor and their interactions within a single, efficient trial, rather than running separate experiments for each factor. |
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