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	GRADE Evidence Profiling: Bedömning av evidenssäkerhet och rekommendationsstyrka	CASP Randomiserad Kontrollerad Rättegångschecklista
Ämnesområde	Forskningsmetodik	Forskningsmetodik
Familj	Process / pipeline	Process / pipeline
Ursprungsår	2008	1993 (updated through 2023)
Upphovsperson	Guyatt et al. (GRADE Working Group)	Critical Appraisal Skills Programme (Oxford, UK)
Typ	Research team / Guideline panel assessment	Clinician-rated / Research team assessment
Ursprungskälla	Guyatt, G., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008). GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ, 336(7650), 924–926.	Critical Appraisal Skills Programme (CASP). (1993, updated). CASP Randomised Controlled Trials Checklist. University of Oxford, UK. www.casp-uk.net
Alias	GRADE, GRADE approach	CASP-RCT, CASP
Närliggande	4	4
Sammanfattning	GRADE (Grading of Recommendations Assessment, Development and Evaluation) is a systematic, transparent framework for assessing the certainty of evidence and determining the strength of clinical recommendations in healthcare. Published in 2008 by Guyatt et al., GRADE has become the international standard for guideline development, used by the World Health Organization, Cochrane, and most major clinical guideline organizations worldwide.	The Critical Appraisal Skills Programme (CASP) RCT Checklist is a practical, widely adopted tool developed by the UK-based Critical Appraisal Skills Programme (founded 1993) for assessing the methodological quality and relevance of published randomized controlled trials. Unlike numeric scoring scales, it uses 11 structured questions with yes/no/cannot tell responses to guide critical appraisal in a format accessible to busy clinicians, researchers, and educators.