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| Solomon fyrgruppsdesign med crossover× | Kors-randomiserad kontrollerad studie× | |
|---|---|---|
| Ämnesområde | Försöksplanering | Försöksplanering |
| Familj | Process / pipeline | Process / pipeline |
| Ursprungsår≠ | 1949 (base design); crossover adaptation developed through later methodological literature | 1960s (Grizzle 1965 for statistical foundations); widely used in clinical research since the 1970s |
| Upphovsperson≠ | Richard L. Solomon (base design); crossover extension via repeated-measures methodology | Early formalized by statisticians including Bradford Hill and colleagues in clinical trials; theoretical framework developed by Grizzle (1965) and later Senn (2002) |
| Typ≠ | Experimental design (pretest-sensitization control + within-subjects crossover) | Experimental within-subject design |
| Ursprungskälla≠ | Solomon, R. L. (1949). An extension of control group design. Psychological Bulletin, 46(2), 137–150. DOI ↗ | Senn, S. (2002). Cross-over Trials in Clinical Research (2nd ed.). Wiley. ISBN: 978-0471496533 |
| Alias≠ | crossover S4G design, within-subjects Solomon design, repeated-measures Solomon four-group design | crossover RCT, crossover trial, within-subject RCT, AB/BA crossover design |
| Närliggande | 5 | 5 |
| Sammanfattning≠ | The Crossover Solomon Four-Group Design merges two powerful experimental strategies: the Solomon four-group design's control for pretest sensitization and the crossover design's within-subjects efficiency. Participants are randomly assigned to one of four groups that vary in whether they receive a pretest and in the sequence of treatment and control conditions, allowing the researcher to simultaneously estimate treatment effects, pretest effects, and their interaction while controlling for individual differences through repeated measurement. | A crossover randomized controlled trial (crossover RCT) is an experimental design in which each participant receives all study interventions in a randomized sequence, separated by a washout period. Because every participant serves as their own control, within-subject variability is eliminated from the treatment comparison, yielding greater statistical power per participant than a parallel-group RCT of equal size. |
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