N-of-1 Trial
An N-of-1 trial is a single-patient randomized controlled trial in which a patient alternates between treatment A and treatment B (or active drug and placebo) in repeated, randomized cross-over periods. Developed systematically in the 1990s–2010s by Kravitz, Duan, and Vohra, N-of-1 trials enable personalized medicine by determining which treatment works best for that specific individual, avoiding the assumption that population-average effects apply to all patients. They are ideal for chronic conditions with variable outcomes and heterogeneous treatment response.
Изворни запис
Цитирани радови су копирани дословно из изворног записа методе. Из њих се не изводи верификација на нивоу тврдње.
- Gabler, N. B., Duan, N., Vohra, S., & Kravitz, R. L. (2011). N-of-1 trials in the medical literature: a systematic review. Medical Care, 49(8), 761–768. · DOI 10.1097/mlr.0b013e318215d90d
- Kravitz, R. L., Duan, N., & Eslick, I. (2010). Evidence-based medicine, heterogeneity of treatment effects, and the trouble with averages. The Milbank Quarterly, 88(4), 503–520. · URL
- Vohra, S., Shamseer, L., Sampson, M., Barrowman, N., Yap, B., Uleryk, E., ... & Moher, D. (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration. BMJ Open, 5(7), e007838. · DOI 10.1136/bmj.h1793
Куроване тврдње
Тврдње су сачуване у регистру доказа, свака са својом проценом.
Овај приказ не измишља процену тврдње када регистар нема ниједну.
Сродне методе
Генерисано из графа метода и приказано као машински предложене везе — не изводи се тврдња доказа.