Krahasoni metodat

	Dërgesa e Barnave Lipozomale	Testi i Permeabilitetit të Qelizave Caco-2
Fusha	Farmakologji	Farmakologji
Familja	Process / pipeline	Process / pipeline
Viti i origjinës	1965	1989
Krijuesi	Alec Bangham	Ingrid Hidalgo
Lloji	formulation technology	absorption screening
Burimi themelues	Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965). Diffusion of univalent ions across the lamellae of swollen phospholipid films and the determination of membrane potential. Journal of Molecular Biology, 13(1), 238-252.	Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96(3), 736-749.
Emërtime të tjera	liposomal formulation, vesicular delivery, lipid nanoparticles	Caco-2 assay, intestinal permeability, ADME screening
Të lidhura	3	3
Përmbledhja	Liposomal encapsulation is a formulation technique using lipid bilayer vesicles (liposomes) to enclose drugs, improving bioavailability, reducing toxicity, and enabling targeted delivery. Developed by Alec Bangham in 1965, liposomes are now standard in pharmaceutical development, with several FDA-approved liposomal drugs on the market.	The Caco-2 assay is an in vitro model system using human colon carcinoma cell monolayers to screen drug intestinal permeability. Developed by Hidalgo and colleagues in 1989, Caco-2 cells differentiate into an epithelial barrier resembling intestinal mucosa, enabling rapid assessment of drug absorption potential and identification of transporter-mediated transport.