Krahasoni metodat

	Studimi Bayesiano Epigenom-Gjerë i Asociacioneve në Kërkimin Arsimor	Analiza e Ndërmjetësimit
Fusha	Bioinformatikë	Statistikë
Familja	Process / pipeline	Hypothesis test
Viti i origjinës	EWAS framework ~2010–2011; Bayesian EWAS variants ~2013–2017; educational applications ~2015–present	1986
Krijuesi	Rakyan, Down, Balding, and Beck (conceptual EWAS framework); Bayesian extensions by multiple groups including Teschendorff and colleagues	Baron & Kenny
Lloji	Genomic association study with Bayesian inference	Indirect effects / path test
Burimi themelues	Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011). Epigenome-wide association studies for common human diseases. Nature Reviews Genetics, 12(8), 529–541.	Baron, R. M. & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research. Journal of Personality and Social Psychology, 51(6), 1173–1182.
Emërtime të tjera	Bayesian EWAS, Bayesian epigenome-wide scan, Bayesian methylation-wide association study, B-EWAS	indirect effects analysis, path-based mediation, PROCESS macro mediation, Aracılık Analizi (Mediation / PROCESS)
Të lidhura	3	5
Përmbledhja	A Bayesian epigenome-wide association study (Bayesian EWAS) scans hundreds of thousands of DNA methylation sites across the genome to identify those statistically associated with an educational outcome — such as cognitive ability, attainment, or socioeconomic exposure during schooling. Unlike classical frequentist EWAS, the Bayesian framework incorporates prior biological knowledge to compute posterior probabilities of association, improving power and reducing false discoveries when applied to complex educational phenotypes.	Mediation analysis is a statistical procedure that tests whether the effect of an independent variable X on an outcome Y operates wholly or partly through a third variable M, called the mediator. Formalised by Baron and Kenny in 1986, it decomposes the total effect of X on Y into a direct path (c′) and an indirect path (a × b), quantifying how much of the relationship is carried by the mediating mechanism.