Krahasoni metodat

	Testimi i Stabilitetit sipas Arrhenius	Farmakovigilanca PRR/ROR
Fusha	Farmakologji	Farmakologji
Familja	Process / pipeline	Process / pipeline
Viti i origjinës	1889	2002
Krijuesi	Svante Arrhenius	Arne Melander and colleagues
Lloji	shelf-life prediction	safety signal detection
Burimi themelues	Arrhenius, S. (1889). Über die Reaktionsgeschwindigkeit bei der Inversion von Rohrzucker durch Säuren. Zeitschrift für Physikalische Chemie, 4, 226-248.	Szarfman, A., Tonning, J. M., Doraiswamy, P. M., & Osgood, D. J. (2002). Pharmacovigilance in the post-marketing setting: establishing causal links between drugs and adverse events. Drug Safety, 25(9), 619-631.
Emërtime të tjera	Arrhenius model, shelf-life prediction, degradation kinetics	PRR, ROR, signal detection, adverse event monitoring
Të lidhura	3	3
Përmbledhja	Arrhenius stability testing predicts pharmaceutical product shelf-life by conducting accelerated degradation studies at elevated temperatures and using the Arrhenius equation to extrapolate to storage conditions. Based on Svante Arrhenius's 1889 equation relating reaction rate to temperature, this method is regulatory standard for establishing expiration dates.	Proportional Reporting Ratio (PRR) and Reporting Odds Ratio (ROR) are statistical methods for detecting safety signals in spontaneous adverse event reporting databases. Developed and formalized by researchers in the early 2000s, these measures identify drug-adverse event associations that warrant further investigation.