Selection Sweep (Tajima's D)
Tajima's D is a statistical test designed to detect selective sweeps—recent, rapid fixation of advantageous mutations—from patterns of genetic variation in DNA sequences. Developed by Fumio Tajima in 1989, this test measures deviations from neutrality by comparing different measures of DNA sequence diversity. A significant Tajima's D value indicates departure from neutral evolution, suggesting positive selection, population structure, or demographic events.
Zdrojový záznam
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- Tajima, F. (1989). Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics, 123(3), 585–595. · DOI 10.1093/genetics/123.3.585
- Braverman, J. M., Hudson, R. R., Kaplan, N. L., Langley, C. H., & Stephan, W. (1995). The hitchhiking effect on the site frequency spectrum of DNA polymorphisms. Genetics, 140(2), 783–796. · DOI 10.1093/genetics/140.2.783
- Fay, J. C., & Wu, C. I. (2000). Hitchhiking under positive Darwinian selection. Genetics, 155(3), 1405–1413. · DOI 10.1093/genetics/155.3.1405
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