Сравнение методов

	Анализ блоков неравновесия по сцеплению (LD)	Картирование количественных признаков (QTL Mapping)
Область	Генетика	Генетика
Семейство	Process / pipeline	Process / pipeline
Год появления	2002	1989
Автор метода	Shaun Gabriel & Eric Lander	Eric Lander & David Botstein
Тип	Haplotype analysis method	Genetic linkage method
Основополагающий источник	Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., & Lander, E. S. (2002). The structure of haplotype blocks in the human genome. Science, 296(5576), 2225–2229.	Lander, E. S., & Botstein, D. (1989). Mapping Mendelian traits using RFLP linkage maps. Genetics, 121(1), 185–199.
Другие названия	Haplotype block analysis, LD mapping, Block structure analysis	QTL analysis, Linkage mapping, Trait locus mapping
Связанные	5	4
Сводка	Linkage disequilibrium (LD) block analysis is a genomic method that partitions the human genome into distinct haplotype blocks—regions of limited recombination where variants are in strong statistical association. First systematically described by Gabriel and colleagues in 2002, this approach reveals the underlying structure of genetic variation and enables efficient genomic studies by reducing the number of variants needed to capture common diversity. LD block analysis forms the foundation of genome-wide association study (GWAS) design and modern population genetics.	Quantitative trait loci (QTL) mapping is a genetic method that localizes chromosomal regions influencing quantitative traits—continuous phenotypes controlled by multiple genes and environmental factors. Developed by Lander and Botstein in 1989, QTL mapping uses linkage analysis and trait variation in segregating populations (such as F2 crosses or recombinant inbred lines) to identify genomic intervals containing loci that substantially affect trait values. This foundational approach has been extended to genome-wide association and is essential for understanding the genetic architecture of complex traits.