Сравнение методов
Просматривайте выбранные методы рядом; строки с различиями подсвечены.
| Поиск по профилю HMMER× | Молекулярное докирование× | |
|---|---|---|
| Область | Биоинформатика | Биоинформатика |
| Семейство | Process / pipeline | Process / pipeline |
| Год появления≠ | 1994 | 1982 |
| Автор метода≠ | Sean Eddy | Irwin Kuntz |
| Тип≠ | Probabilistic sequence search pipeline | Binding prediction pipeline |
| Основополагающий источник≠ | Krogh, A., Brown, M., Mian, I. S., Sjölander, K., & Haussler, D. (1994). Hidden Markov models in computational biology: applications to protein modeling. Journal of Molecular Biology, 235(5), 1501-1531. DOI ↗ | Kuntz, I. D., Blaney, J. M., Oatley, S. J., Langridge, R., & Ferrin, T. E. (1982). A geometric approach to macromolecule-ligand interactions. Journal of Molecular Biology, 161(2), 269-288. DOI ↗ |
| Другие названия≠ | profile-hidden Markov model, HMM profile search, HMMER | protein-ligand docking, binding prediction |
| Связанные≠ | 3 | 4 |
| Сводка≠ | HMMER profile search identifies distant protein sequence homologs using probabilistic models of protein families, known as profile Hidden Markov Models (HMMs). Developed by Eddy and colleagues, this method captures sequence variation patterns within protein families and detects homologs with far greater sensitivity than position-weight matrices or pairwise alignment. | Molecular docking predicts the preferred binding orientation and affinity of a ligand (small molecule) within a protein binding pocket. Pioneered by Kuntz and colleagues in 1982, this computational method searches conformational space to find energetically favorable ligand-protein complexes, enabling rapid screening of chemical libraries for drug discovery. |
| ScholarGateНабор данных ↗ |
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