Сравнение методов
Просматривайте выбранные методы рядом; строки с различиями подсвечены.
| Клеточный тест на проницаемость Caco-2× | Фактор подобия растворения f1/f2× | |
|---|---|---|
| Область | Фармакология | Фармакология |
| Семейство | Process / pipeline | Process / pipeline |
| Год появления≠ | 1989 | 1996 |
| Автор метода≠ | Ingrid Hidalgo | James Moore and Hector Flanner |
| Тип≠ | absorption screening | similarity testing |
| Основополагающий источник≠ | Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96(3), 736-749. DOI ↗ | Moore, J. W., & Flanner, H. H. (1996). Mathematical comparison of dissolution profiles. Pharmaceutical Technology, 20(6), 64-74. link ↗ |
| Другие названия | Caco-2 assay, intestinal permeability, ADME screening | f1, f2, similarity factor |
| Связанные | 3 | 3 |
| Сводка≠ | The Caco-2 assay is an in vitro model system using human colon carcinoma cell monolayers to screen drug intestinal permeability. Developed by Hidalgo and colleagues in 1989, Caco-2 cells differentiate into an epithelial barrier resembling intestinal mucosa, enabling rapid assessment of drug absorption potential and identification of transporter-mediated transport. | The f1 and f2 factors are dimensionless statistical measures developed by Moore and Flanner to quantify the similarity between two dissolution profiles. Adopted by regulatory agencies (FDA, EMA) as the gold standard for comparing dissolution curves, these factors enable rapid assessment of whether formulation changes significantly impact drug release. |
| ScholarGateНабор данных ↗ |
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