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| Modelowanie molekularne× | Modelowanie homologiczne× | |
|---|---|---|
| Dziedzina | Bioinformatyka | Bioinformatyka |
| Rodzina | Process / pipeline | Process / pipeline |
| Rok powstania≠ | 1982 | 1993 |
| Twórca≠ | Irwin Kuntz | Andrej Sali |
| Typ≠ | Binding prediction pipeline | Comparative structure prediction pipeline |
| Źródło pierwotne≠ | Kuntz, I. D., Blaney, J. M., Oatley, S. J., Langridge, R., & Ferrin, T. E. (1982). A geometric approach to macromolecule-ligand interactions. Journal of Molecular Biology, 161(2), 269-288. DOI ↗ | Sali, A. & Blundell, T. L. (1993). Comparative protein modelling by satisfaction of spatial restraints. Journal of Molecular Biology, 234(3), 779-815. DOI ↗ |
| Inne nazwy | protein-ligand docking, binding prediction | comparative modeling, template-based modeling |
| Pokrewne | 4 | 4 |
| Podsumowanie≠ | Molecular docking predicts the preferred binding orientation and affinity of a ligand (small molecule) within a protein binding pocket. Pioneered by Kuntz and colleagues in 1982, this computational method searches conformational space to find energetically favorable ligand-protein complexes, enabling rapid screening of chemical libraries for drug discovery. | Homology modeling, also called comparative modeling, predicts the three-dimensional structure of a protein using an experimentally-solved structure of a homologous protein as a template. Introduced by Sali and Blundell in 1993, this method exploits the principle that homologous proteins share similar spatial structures despite differing in amino acid sequence. |
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